Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, is a devastating disease that is present in all major soybean-producing regions. The limited availability of resistant germplasm has resulted in a scarcity of commercial soybean cultivars that are resistant to the disease. To date, only the Chinese soybean landrace SX6907 has demonstrated an immune response to ASR. In this study, we present the isolation and characterization of Rpp6907-7 and Rpp6907-4, a gene pair that confer broad-spectrum resistance to ASR. Rpp6907-7 and Rpp6907-4 encode atypic nucleotide-binding leucine-rich repeat (NLR) proteins that are found to be required for NLR-mediated immunity. Genetic analysis shows that only Rpp6907-7 confers resistance, while Rpp6907-4 regulates Rpp6907-7 signaling activity by acting as a repressor in the absence of recognized effectors. Our work highlights the potential value of using Rpp6907 in developing resistant soybean cultivars.
国内外缺乏大豆条锈病抗病基因，而本文实现了从0到1的突破，成功定位到了大豆抗条锈病基因Rpp6907-7，并且通过转基因验证其功能，此外还发现Rpp6907-4和Rpp6907-7存在互作关系。
Fig. 1 | Cloning and functional characterization of Rpp6907-7
Fig. 2 | Evolutionary of the NLR encoding genes at the Rpp6907 locus.
Fig. 3 | Molecular characteristics, tissue distribution, and protein structure of Rpp6907-7.
Fig. 4: Rpp6907-4 heterodimerizes interact with Rpp6907-7 and suppresses Rpp6907-7-mediated resistance.
点评：实现了从0-1的突破，为大豆育种提供了难能可贵的基因是这篇文章的亮点和主要贡献！
